Health: Side Effects of Paracetamol,by Pharm shaff

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by: Pharm shaff

Acetaminophen, popular Called Paracetamol, is a medicine use in the treatment of pain and fever.

It is used in treatment of mild to moderate pain. It is often sold in combination with other medications, such as some cold medications.

In combination with opioid pain medication, paracetamol is also used for severe pain such as cancer pain and pain after surgery.

Indications:
This refers to the conditions in which the drug is relevant for. The indications for paracetamol include;
-low back pain, headaches (combined with caffeine in case of migraine), postoperative pain (often with NSAIDS), dental pain (with NSAIDS).
The efficacy of paracetamol when used in combination with weak opioids (such as codeine) improved for approximately 50% of people but with increase in the number experiencing side effects. Combination with strong opioids (like morphine) improve analgesic effect as well as combination with caffeine.

Patent ductus arteriosus:

A condition that affects newborns when a blood vessel used in developing the lungs fails to close as it normally does. Nonsteroidal anti-inflammatory drugs (NSAIDS), particularly indomethacin and ibuprofen have also been used.

Dosage:
A tablet of paracetamol often contains 500mg active ingredient (acetaminophen), maximum dose per day for an adult is 3g (six tablets) while for a child is about 1.5g (three tablets).
Adult : two tablets three times in a day Child(6-12years): one tablet three times in a day
6years: ask your doctor or pharmacist

Side Effects
The most frequently reported side effect is fever. Other side effects occur but are rare, these are meant to be reported to a doctor or pharmacist if encountered.

They include;
Bloody or black, tarry stool
Bloody or cloudy urine
Pain in the lower back, Skin rash
Sore throat, Ulcer, Sudden decrease in amount of urine
Weakness Yellow eyes or skin
Symptoms of overdose include;
Diarrhea, Increased sweating
Loss of appetite, Vomiting,
Stomach pain, Swelling, pain or tenderness of the upper abdomen or stomach area.

Adverse Effects
This refers to the effects of overdosage or misuse of drug. They include;
Liver damage
Skin reactions
Asthma
Kidney failure etc

Pregnancy
In administration of drugs to pregnant women, extra care must be taken so as not to harm the foetus.
Experimental studies in animals and cohorts studies in humans indicate no detectable increase in congenital malformations associated with paracetamol use during pregnancy. It does not affect the closure of the foetal ductus arteriosus as Nonsteroidal anti-inflammatory drugs can.

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1 COMMENT

  1. Nice write-up Pharm Shaff. I get to relate laboratory testings in a lot of the effects mentioned in your write-up. Ranging from stool analysis, urinalysis, urine m/c/s, stool m/c/s and other body fluids testings. Your article incorporated all fields in health profession. Keep it up bro

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